In studies of scientific methodology, surprisingly little attention has been given to tests of hypotheses. Such testing constitutes a methodology common to various scientific disciplines and is an essential factor in the development of science since it determines which theories are retained. The classical theory of tests is a major accomplishment but requires modification in order to produce a theory that accounts for the success of science. The revised theory is an analysis of the nondeductive aspect of scientific reasoning. It (...) results in a new definition of probability and a nonclassical point of view with regard to the foundations of probability. (shrink)

The host actin nucleation machinery is subverted by many bacterial pathogens to facilitate their entry, motility, replication, and survival. The majority of research conducted in the past primarily focused on exploitation of a host actin nucleator, the Arp2/3 complex, by bacterial pathogens. Recently, new studies have begun to explore the role of formins, another family of host actin nucleators, in bacterial pathogenesis. This review provides an overview of recent advances in the study of the exploitation of the Arp2/3 complex and (...) formins by bacterial pathogens. Secreted bacterial effector proteins seem to manipulate the regulation of these actin nucleators or functionally mimic them to drive bacterial entry, motility and survival within host cells. An enhanced understanding of how formins are exploited will provide us with greater insight into how a fundamental eurkaryotic cellular process is utilized by bacteria and will also advance our knowledge of host‐pathogen interactions. (shrink)

Ignoring the temporal dimension, an object such as a railway tunnel or a human body is a three-dimensional whole composed of three-dimensional parts. The four-dimensionalist holds that a physical object exhibiting identity across time—Descartes, for example—is a four-dimensional whole composed of 'briefer' four-dimensional objects, its temporal parts. Peter van Inwagen (1990) has argued that four-dimensionalism cannot be sustained, or at best can be sustained only by a counterpart theorist. We argue that different schemes of individuation of temporal parts are available, (...) which undermines van Inwagen's argument. (shrink)

In studies of scientific methodology, surprisingly little attention has been given to tests of hypotheses. Such testing constitutes a methodology common to various scientific disciplines and is an essential factor in the development of science since it determines which theories are retained. The classical theory of tests is a major accomplishment but requires modification in order to produce a theory that accounts for the success of science. The revised theory is an analysis of the nondeductive aspect of scientific reasoning. It (...) results in a new definition of probability and a nonclassical point of view with regard to the foundations of probability. (shrink)

In studies of scientific methodology, surprisingly little attention has been given to tests of hypotheses. Such testing constitutes a methodology common to various scientific disciplines and is an essential factor in the development of science since it determines which theories are retained. The classical theory of tests is a major accomplishment but requires modification in order to produce a theory that accounts for the success of science. The revised theory is an analysis of the nondeductive aspect of scientific reasoning. It (...) results in a new definition of probability and a nonclassical point of view with regard to the foundations of probability. (shrink)

Discusses central aspects of Kant's work on the nature of morality and the basis of moral obligation. In examining the categorical imperative and the hypothetical imperative, emphasizes the real nature of the distinction between these principles: whereas the former is binding upon every one, the latter is binding only upon some individuals, namely those individuals who want the end for which a prescribed action is a means. Also considers the nature of the will, Kant's criterion of the rightness of a (...) right action, and two criticisms of Kant's view of morality that arise from his attempt to offer a general answer to the question ‘Why ought an action be performed?’ Then turns to Kant's proof of freedom, which it is claimed just barely misses making the right point that action is only possible under the idea of freedom. Concludes by examining Kant's proof of immortality and the existence of God. (shrink)

Prichard's topic here is the nature of ‘ought’. If we were to take ‘I ought to will x’ to be equivalent to ‘my willing x ought to exist’, then it is true that ‘If I were to will a certain change x, my willing x would be something that ought to exist.’ For this to hold, either my willing x would itself be something good or my willing x would cause something good. Prichard, however, rejects this view on the grounds (...) that one cannot know, in willing x to exist, whether one's willing x is something that ought to exist. One can only know that if one were to will x, one would be willing something that one thought ought to exist. (shrink)

The act of exchanging one thing for another seems to involve a promise. The confidence needed to relinquish something one has on the understanding that one will receive what another has in exchange can be expressed in terms of resolve. In binding oneself, one thinks that if the other binds himself or herself to perform a given action, then he or she will do that action. In cases in which one person's action does not precede the other's, one's promise involves (...) thinking that if the other binds himself or herself, then he or she will carry out the promised action. (shrink)

Analyses Green's rather obscure treatment of two important questions: ‘Why does a subject have the duty to obey the ruler or sovereign?’; and ‘Why is the receipt of an order backed by a threat sufficient to establish this duty when the order comes from a ruler?’ Prichard considers Green's position regarding the grounds and justification for obedience to law to be part of a larger theory of moral obligation that is inconsistent with our ordinary moral ideas. To Green's seeming denial (...) of the existence of any natural rights or duties, Prichard responds that Green in fact has failed to state a sense in which there really are natural rights and obligations. Moreover, Green's denial that we can answer the question ‘Why ought we to obey the government?’ can be formulated only by maintaining the existence of an obligation independent of our government's commands. The core of truth in Green's position, according to Prichard, lies in his recognition that a factor necessary to secure obedience is the subject's unselfish interest in the welfare of other members of her community. (shrink)

Endeavours to specify what Aristotle means by αγαθον. In some contexts, this term seems to mean simply ‘that being desired’ or a person's ultimate or non‐ultimate end or aim. In other contexts, αγαθον takes on a normative quality. For his statements to have content, argues Prichard, Aristotle must hold that when we pursue something of a certain kind, such as an honour, we pursue it as a good. Prichard argues that by αγαθον Aristotle actually means ‘conducive to happiness’, and holds (...) that when a man acts deliberately, he does it from a desire to be happy. Prichard attributes this position to Plato as well, despite the fact that both thinkers make statements inconsistent with this view of our ultimate aim. (shrink)

Often an action causes both evil and benefit for the agent. No general account can be given for what happens when one considers in light of this evil and benefit whether to undertake the action in question. Prichard maintains that in willing a movement, there are two acts of will. First, there is the willing to think more of what one shall gain in willing x, which results from the desire to will x. Second, there is the willing of the (...) change x. (shrink)

The Bhagavad-Gītā is the most important text in the smrti literature of India, as distinct from the śruti literature which is traditionally regarded as ultimately authoritative. The Bhagavad-Gītā has been assigned a date ranging from the fifth century B.C. to the second century B.C. The Indian religious tradition places the Gītā at the end of the third age of the present cycle of the universe and the beginning of the fourth, namely the Kali Yuga to which we belong.

"The studies collected in this book are all concerned with aspects of the Platonic tradition, either in its own internal development in the Hellenistic age and the period of the Roman Empire, or with the influence of Platonism, in one or other of its forms, on other spiritual traditions, especially that of Christianity." [Book jacket].

A. H. Louie's More Than Life Itself is an exploratory journey in relational biology, a study of life in terms of the organization of entailment relations in living systems. This book represents a synergy of the mathematical theories of categories, lattices, and modelling, and the result is a synthetic biology that provides a characterization of life. Biology extends physics. Life is not a specialization of mechanism, but an expansive generalization of it. Organisms and machines share some common features, but organisms (...) are not machines. Life is defined by a relational closure that places it beyond the reach of physicochemical and mechanistic dogma, outside the reductionistic universe, and into the realm of impredicativity. Function dictates structure. Complexity brings forth living beings. (shrink)

All-encompassing text examines every aspect of coma from neurochemistry, monitoring, and treatments to prognostic factors.

In the early 1970s, we and others in the economics profession became enamored with the notion of externalties—a cost or benefit imposed on or provided to others but not taken into account by the economic agents who generate the effect. We, and others, seemed to see external effects everywhere. There was polluted water and air, noise, urban blight, traffic congestion, and other features of modern life that seemed to call out for some form of corrective action. As the externalities revolution (...) unfolded, economists and other social scientists overlooked the importance of evolved legal and other institutions that formally and informally establish property and liability rules that cause decision makers to face the cost of their actions, including what otherwise could be external costs imposed on unwilling third parties. While markets seemed always to fail, political institutions were seen systematically as without blemish, or so it seemed. It was this two-pronged failure, 1) a failure to consider and state assumptions about background institutional arrangements and 2) a disregard for special interest politics, that became the Achilles Heel of the otherwise elegant externality arguments. Eventually, it was the modern institutionalists, scholars who focused on laws, regulation, and rules of the marketplace, who attempted to close the lid and drive the nails on the externality coffin. In this paper, we reach back to 1920 and trace the rise and decline of the policy importance of externalities theory. Beginning with A. C. Pigou and Alfred Marshall, our story includes some of the great figures in economic history of thought. But while theory was being built, institutions were overlooked. Pigou continues to be a dominant player in the story until the 1960s and 1970s when externalities theory was challenged by James M. Buchanan, Ronald Coase and other scholars. It is here in the twilight years of the externalities revolution that the prospects of government failure are raised as being more daunting than the likelihood of market failure. Finally, in the late 1970s and beyond, the externalities revolution is replaced by a property rights revolution. (shrink)

Edited with New Translation by Richard McKirahan With a New Preface by Malcolm Schofield This book is a revised and expanded version of A.H. Coxon's full critical edition of the extant remains of Parmenides of Elea—the fifth-century B.C. philosopher by many considered "one of the greatest and most astonishing thinkers of all times." Coxon's presentation of the complete ancient evidence for Parmenides and his comprehensive examination of the fragments, unsurpassed to this day, have proven invaluable to our understanding of the (...) Eleatic since the book's first publication in 1986. This edition, edited by Richard McKirahan and with a new preface by Malcolm Schofield, is released on the 100th anniversary of Coxon's birth. This new edition for the first time includes English translations of the testimonia and of any Ancient Greek throughout the book, as well as an English/Greek glossary by Richard McKirahan, and revisions by the late author himself. The text consists of Coxon's collations of the relevant folios of manuscripts of Sextus Empiricus, Proclus and Simplicius and includes all extant fragments, a commentary, the testimonia, a complete list of sources, linguistic parallels from both earlier and later authors, and the fullest critical apparatus that has appeared since Diels’ _Poetarum Philosophorum Fragmenta _. The collection of testimonia includes the philosophical discussions of Parmenides by Plato, Aristotle and the Neoplatonists, most of which had been omitted by Diels. The introduction discusses the history of the text, the language and form of the poem, Parmenides’ use and understanding of the verb ‘to be’, his place in the history of earlier and later philosophy and the biographical tradition. In the commentary Coxon deals in detail with both the language and the subject matter of the poem and pays full attention to Parmenides’ account of the physical world. The appendix relates later Eleatic arguments to those of Parmenides. (shrink)

This is the first-ever critical history of sociology in Britain, written by one of the world's leading scholars in the field. A. H. Halsey presents a vivid and authoritative picture of the neglect, expansion, fragmentation, and explosion of the discipline during the past century. The book examines the literary and scientific contributions to the origin of the discipline, and the challenges faced by the discipline at the dawn of a new century.

Aristophanes' last two surviving plays, Assemblywomen and Wealth, have long been regarded as something of an enigma. The changes in structure – the diminution in the role of the chorus, the disappearance of the parabasis, etc. –, as well as the shift of interest away from the immediacies of current politics towards broader social themes, can reasonably be interpreted as an early stage of the process that ultimately transformed Old Comedy into New, even if it is unlikely ever to be (...) finally agreed whether Aristophanes was leading or following this trend. The decline in freshness, in verbal agility, in sparkle of wit, in theatrical inventiveness, which is perceptible in the earlier play and very marked in the later, may be put down to advancing years and diminishing inspiration. Such an explanation squares with the evidence of a marked decline in Aristophanes' productivity towards the end of his life. Whereas in the first seven years of his career he seems to have produced, or had produced for him, not less than ten plays, and in the years 420–405 approximately another eighteen, the twenty years or so that followed Frogs yielded a further eleven at the very most unless some titles have been completely lost; and since it is not likely that after the outstanding success of Frogs, and the public recognition that followed it, Aristophanes would have experienced any difficulty in securing a chorus, the explanation can only be that he was writing less. But the truly puzzling feature of the two late plays we possess is the apparent sea-change in the author's social orientation. In his fifth-century plays, from Acharnians toFrogs, as has been shown by de Ste Croix, Aristophanes reveals himself as one who instinctively speaks the language and thinks the thoughts of the well-to-do, even if at the same time he can laugh with the common man at ostentatious and useless wealth in the shape of Pyrilampes' peacocks, Leogoras' pheasants or the sultan-like garments of an Athenian imperial official – as one who was happy for the Demos to be sovereign so long as it was willing to be guided by the advice of its' betters', the καλоί тε κáγоθоί of Knights 738 or Frogs 727–9, and to leave them in the quiet enjoyment of their property. At first sight in Assemblywomen and Wealth this seems to have changed almost diametrically. (shrink)

The phenomenological calculus is a relational paradigm for complex systems, closely related in substance and spirit to Robert Rosen’s own approach. Its mathematical language is multilinear algebra. The epistemological exploration continues in this paper, with the expansion of the phenomenological calculus into the realm of anisotropy.

On the basis of previous studies in relational biology and the phenomenological calculus, in my contribution I outline the mathematical foundations of biological perception generally, and visual perception specifically. In this approach, the premise is that objects in nature are not directly accessible, and that real manifestations are projections of these invariant objects. The morphology of observables is mathematically entailed by the duality of projections and projectors in a bilinear algebra that is the phenomenological calculus. The relationships between what is (...) not directly accessible (which can be defined as noumena) and phenomena may be explicated in terms of metabolism and repair, whence a geometric theory of the perceived, the visible in particular, may be formulated in the category-theoretic language of relational biology. (shrink)